Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4640370..4640879 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N5O75_RS23015 Protein ID WP_001173343.1
Coordinates 4640370..4640543 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag N5O75_RS23020 Protein ID WP_261306905.1
Coordinates 4640571..4640879 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS23005 (4637040) 4637040..4638497 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
N5O75_RS23010 (4638734) 4638734..4640251 + 1518 WP_001295074.1 lysine--tRNA ligase -
N5O75_RS23015 (4640370) 4640370..4640543 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N5O75_RS23020 (4640571) 4640571..4640879 - 309 WP_261306905.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N5O75_RS23030 (4642430) 4642430..4642702 - 273 WP_000405649.1 GNAT family N-acetyltransferase -
N5O75_RS23035 (4642714) 4642714..4642944 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
N5O75_RS23040 (4643125) 4643125..4644756 + 1632 WP_001216486.1 sensor histidine kinase -
N5O75_RS23045 (4644753) 4644753..4645472 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(9-98)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T258152 WP_001173343.1 NZ_CP104500:c4640543-4640370 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11789.29 Da        Isoelectric Point: 4.1705

>AT258152 WP_261306905.1 NZ_CP104500:c4640879-4640571 [Escherichia coli]
IGANPEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLD
LPDIDFDLNIMTVDDYFRQFYK

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References