258150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4493412..4494007 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name chpB Uniprot ID A0A3L3YDL1
Locus tag N5O75_RS22265 Protein ID WP_000239576.1
Coordinates 4493412..4493762 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N5O75_RS22270 Protein ID WP_001223208.1
Coordinates 4493756..4494007 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS22245 (4488688) 4488688..4489710 - 1023 WP_001296689.1 ABC transporter permease -
N5O75_RS22250 (4489724) 4489724..4491226 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
N5O75_RS22255 (4491536) 4491536..4492492 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N5O75_RS22260 (4492802) 4492802..4493332 + 531 WP_000055075.1 inorganic diphosphatase -
N5O75_RS22265 (4493412) 4493412..4493762 - 351 WP_000239576.1 endoribonuclease toxin ChpB Toxin
N5O75_RS22270 (4493756) 4493756..4494007 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N5O75_RS22275 (4494219) 4494219..4494560 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N5O75_RS22280 (4494563) 4494563..4498342 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12566.53 Da        Isoelectric Point: 6.2232

>T258150 WP_000239576.1 NZ_CP104500:c4493762-4493412 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT258150 WP_001223208.1 NZ_CP104500:c4494007-4493756 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L3YDL1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References