Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 4430099..4430800 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name ykfI Uniprot ID A0A3L9JQV5
Locus tag N5O75_RS21960 Protein ID WP_038977124.1
Coordinates 4430099..4430434 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3L1KVZ6
Locus tag N5O75_RS21965 Protein ID WP_000939437.1
Coordinates 4430465..4430800 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS21940 (4426073) 4426073..4427334 - 1262 Protein_4296 tyrosine-type recombinase/integrase -
N5O75_RS21945 (4427730) 4427730..4428677 - 948 WP_038977127.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
N5O75_RS21950 (4428670) 4428670..4429065 - 396 WP_038977126.1 DUF6088 family protein -
N5O75_RS21955 (4429135) 4429135..4429968 - 834 WP_038977125.1 DUF4942 domain-containing protein -
N5O75_RS21960 (4430099) 4430099..4430434 - 336 WP_038977124.1 TA system toxin CbtA family protein Toxin
N5O75_RS21965 (4430465) 4430465..4430800 - 336 WP_000939437.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N5O75_RS21970 (4430800) 4430800..4431273 - 474 WP_038977123.1 DNA repair protein RadC -
N5O75_RS21975 (4431303) 4431303..4432121 - 819 WP_033800492.1 DUF932 domain-containing protein -
N5O75_RS21980 (4432357) 4432357..4433310 - 954 WP_038977122.1 hypothetical protein -
N5O75_RS21985 (4433903) 4433903..4434517 + 615 WP_000772911.1 inovirus Gp2 family protein -
N5O75_RS21990 (4434635) 4434635..4434853 + 219 WP_001064742.1 AlpA family phage regulatory protein -
N5O75_RS21995 (4435056) 4435056..4435334 - 279 WP_261306838.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4399781..4448968 49187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(10-110)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12802.79 Da        Isoelectric Point: 8.9372

>T258149 WP_038977124.1 NZ_CP104500:c4430434-4430099 [Escherichia coli]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVDAVNFLVEKYELIRIDRKGF
SWQEQTPYLRAVDILRARQATGLLRRCHNTP

Download         Length: 336 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12556.56 Da        Isoelectric Point: 7.6977

>AT258149 WP_000939437.1 NZ_CP104500:c4430800-4430465 [Escherichia coli]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9JQV5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L1KVZ6

References