258148

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4427730..4429065 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name sanaT Uniprot ID A0A3L9IFW6
Locus tag N5O75_RS21945 Protein ID WP_038977127.1
Coordinates 4427730..4428677 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A3L2P891
Locus tag N5O75_RS21950 Protein ID WP_038977126.1
Coordinates 4428670..4429065 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS21930 (4423861) 4423861..4424403 + 543 WP_001115385.1 hypothetical protein -
N5O75_RS21935 (4424400) 4424400..4425869 + 1470 WP_001022619.1 serine/threonine-protein kinase -
N5O75_RS21940 (4426073) 4426073..4427334 - 1262 Protein_4296 tyrosine-type recombinase/integrase -
N5O75_RS21945 (4427730) 4427730..4428677 - 948 WP_038977127.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N5O75_RS21950 (4428670) 4428670..4429065 - 396 WP_038977126.1 DUF6088 family protein Antitoxin
N5O75_RS21955 (4429135) 4429135..4429968 - 834 WP_038977125.1 DUF4942 domain-containing protein -
N5O75_RS21960 (4430099) 4430099..4430434 - 336 WP_038977124.1 TA system toxin CbtA family protein -
N5O75_RS21965 (4430465) 4430465..4430800 - 336 WP_000939437.1 type IV toxin-antitoxin system YeeU family antitoxin -
N5O75_RS21970 (4430800) 4430800..4431273 - 474 WP_038977123.1 DNA repair protein RadC -
N5O75_RS21975 (4431303) 4431303..4432121 - 819 WP_033800492.1 DUF932 domain-containing protein -
N5O75_RS21980 (4432357) 4432357..4433310 - 954 WP_038977122.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4399781..4448968 49187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35634.77 Da        Isoelectric Point: 4.8847

>T258148 WP_038977127.1 NZ_CP104500:c4428677-4427730 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSSVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSQLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYEMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14586.86 Da        Isoelectric Point: 11.5650

>AT258148 WP_038977126.1 NZ_CP104500:c4429065-4428670 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVHYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9IFW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3L2P891

References