258145

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3789065..3789683 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N5O75_RS18970 Protein ID WP_001291435.1
Coordinates 3789465..3789683 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N5O75_RS18965 Protein ID WP_000344800.1
Coordinates 3789065..3789439 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS18955 (3784154) 3784154..3785347 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5O75_RS18960 (3785370) 3785370..3788519 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N5O75_RS18965 (3789065) 3789065..3789439 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N5O75_RS18970 (3789465) 3789465..3789683 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N5O75_RS18975 (3789855) 3789855..3790406 + 552 WP_000102564.1 maltose O-acetyltransferase -
N5O75_RS18980 (3790522) 3790522..3790992 + 471 WP_000136192.1 YlaC family protein -
N5O75_RS18985 (3791156) 3791156..3792706 + 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N5O75_RS18990 (3792748) 3792748..3793101 - 354 WP_261306832.1 DUF1428 family protein -
N5O75_RS19000 (3793480) 3793480..3793791 + 312 WP_000409911.1 MGMT family protein -
N5O75_RS19005 (3793822) 3793822..3794394 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258145 WP_001291435.1 NZ_CP104500:3789465-3789683 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258145 WP_000344800.1 NZ_CP104500:3789065-3789439 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References