Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1405036..1405661 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag N5O75_RS06815 Protein ID WP_000911329.1
Coordinates 1405263..1405661 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N5O75_RS06810 Protein ID WP_000450524.1
Coordinates 1405036..1405263 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS06785 (1400838) 1400838..1401308 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N5O75_RS06790 (1401308) 1401308..1401880 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N5O75_RS06795 (1402026) 1402026..1402904 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N5O75_RS06800 (1402921) 1402921..1403955 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N5O75_RS06805 (1404168) 1404168..1404881 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N5O75_RS06810 (1405036) 1405036..1405263 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N5O75_RS06815 (1405263) 1405263..1405661 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
N5O75_RS06820 (1405808) 1405808..1406671 + 864 WP_001267495.1 neutral zinc metallopeptidase -
N5O75_RS06825 (1406686) 1406686..1408701 + 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
N5O75_RS06830 (1408775) 1408775..1409473 + 699 WP_000679812.1 esterase -
N5O75_RS06835 (1409583) 1409583..1409783 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T258138 WP_000911329.1 NZ_CP104500:1405263-1405661 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT258138 WP_000450524.1 NZ_CP104500:1405036-1405263 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References