Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 942800..943454 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag N5O75_RS04650 Protein ID WP_000244772.1
Coordinates 943047..943454 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N5O75_RS04645 Protein ID WP_000354046.1
Coordinates 942800..943066 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS04620 (937969) 937969..938712 + 744 WP_000951964.1 SDR family oxidoreductase -
N5O75_RS04625 (938769) 938769..940202 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
N5O75_RS04630 (940247) 940247..940558 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
N5O75_RS04635 (940722) 940722..941381 + 660 WP_000250274.1 hemolysin III family protein -
N5O75_RS04640 (941577) 941577..942557 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
N5O75_RS04645 (942800) 942800..943066 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N5O75_RS04650 (943047) 943047..943454 + 408 WP_000244772.1 protein YgfX Toxin
N5O75_RS04655 (943494) 943494..944015 - 522 WP_001055874.1 flavodoxin FldB -
N5O75_RS04660 (944127) 944127..945023 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N5O75_RS04665 (945048) 945048..945758 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5O75_RS04670 (945764) 945764..947497 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T258136 WP_000244772.1 NZ_CP104500:943047-943454 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT258136 WP_000354046.1 NZ_CP104500:942800-943066 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References