258133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 320407..320993 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag N5O75_RS01475 Protein ID WP_042014162.1
Coordinates 320407..320637 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N5O75_RS01480 Protein ID WP_032267522.1
Coordinates 320634..320993 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS01465 (316444) 316444..319179 + 2736 WP_000149124.1 ribosome-associated ATPase/putative transporter RbbA -
N5O75_RS01470 (319179) 319179..320303 + 1125 WP_001314210.1 ABC transporter permease -
N5O75_RS01475 (320407) 320407..320637 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
N5O75_RS01480 (320634) 320634..320993 + 360 WP_032267522.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N5O75_RS01485 (321113) 321113..321514 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N5O75_RS01490 (321520) 321520..322326 - 807 WP_038977222.1 nickel import ATP-binding protein NikE -
N5O75_RS01495 (322323) 322323..323087 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
N5O75_RS01500 (323087) 323087..323920 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N5O75_RS01505 (323917) 323917..324861 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T258133 WP_042014162.1 NZ_CP104500:320407-320637 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13418.27 Da        Isoelectric Point: 5.1987

>AT258133 WP_032267522.1 NZ_CP104500:320634-320993 [Escherichia coli]
MIKLKTPNSMEIAGQPSVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure

References