Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 899280..900875 Replicon chromosome
Accession NZ_CP104499
Organism Ralstonia pseudosolanacearum strain Sw698

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag NQS37_RS20325 Protein ID WP_069079583.1
Coordinates 899280..900617 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag NQS37_RS20330 Protein ID WP_016725279.1
Coordinates 900621..900875 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQS37_RS20300 (NQS37_20300) 894935..895675 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
NQS37_RS20305 (NQS37_20305) 895672..896370 + 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
NQS37_RS20310 (NQS37_20310) 896518..897114 + 597 WP_016725451.1 RNA 2',3'-cyclic phosphodiesterase -
NQS37_RS20315 (NQS37_20315) 897127..897855 - 729 WP_011001393.1 DsbA family protein -
NQS37_RS20320 (NQS37_20320) 898081..899283 - 1203 WP_064047701.1 MFS transporter -
NQS37_RS20325 (NQS37_20325) 899280..900617 - 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
NQS37_RS20330 (NQS37_20330) 900621..900875 - 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
NQS37_RS20335 (NQS37_20335) 900979..901818 - 840 WP_016725278.1 oxaloacetate decarboxylase -
NQS37_RS20340 (NQS37_20340) 902136..902774 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
NQS37_RS20345 (NQS37_20345) 902842..903318 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
NQS37_RS20350 (NQS37_20350) 903338..903889 + 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
NQS37_RS20355 (NQS37_20355) 903886..904812 + 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T258131 WP_069079583.1 NZ_CP104499:c900617-899280 [Ralstonia pseudosolanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT258131 WP_016725279.1 NZ_CP104499:c900875-900621 [Ralstonia pseudosolanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References