Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1030811..1031444 Replicon chromosome
Accession NZ_CP104498
Organism Ralstonia pseudosolanacearum strain Sw698

Toxin (Protein)


Gene name vapC Uniprot ID M4UIT8
Locus tag NQS37_RS04940 Protein ID WP_016725172.1
Coordinates 1031031..1031444 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag NQS37_RS04935 Protein ID WP_011002949.1
Coordinates 1030811..1031044 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQS37_RS04920 (NQS37_04920) 1026399..1027694 - 1296 WP_011002952.1 MFS transporter -
NQS37_RS04925 (NQS37_04925) 1027702..1028934 - 1233 WP_021155141.1 AGE family epimerase/isomerase -
NQS37_RS04930 (NQS37_04930) 1029147..1030754 + 1608 WP_069079162.1 glucan biosynthesis protein -
NQS37_RS04935 (NQS37_04935) 1030811..1031044 + 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NQS37_RS04940 (NQS37_04940) 1031031..1031444 + 414 WP_016725172.1 PIN domain-containing protein Toxin
NQS37_RS04945 (NQS37_04945) 1031419..1032045 - 627 WP_016725173.1 DUF1415 domain-containing protein -
NQS37_RS04950 (NQS37_04950) 1032236..1032607 + 372 WP_016725174.1 hypothetical protein -
NQS37_RS04955 (NQS37_04955) 1032672..1034168 - 1497 WP_016725175.1 glycerol kinase GlpK -
NQS37_RS04960 (NQS37_04960) 1034330..1036066 - 1737 WP_016725176.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15087.42 Da        Isoelectric Point: 5.5348

>T258130 WP_016725172.1 NZ_CP104498:1031031-1031444 [Ralstonia pseudosolanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT258130 WP_011002949.1 NZ_CP104498:1030811-1031044 [Ralstonia pseudosolanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4UIT8

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References