Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2493826..2495421 Replicon chromosome
Accession NZ_CP104496
Organism Ralstonia pseudosolanacearum strain Gj707

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag NQS38_RS11900 Protein ID WP_069079583.1
Coordinates 2493826..2495163 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag NQS38_RS11905 Protein ID WP_016725279.1
Coordinates 2495167..2495421 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQS38_RS11875 (NQS38_11875) 2489481..2490221 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
NQS38_RS11880 (NQS38_11880) 2490218..2490916 + 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
NQS38_RS11885 (NQS38_11885) 2491064..2491660 + 597 WP_016725451.1 RNA 2',3'-cyclic phosphodiesterase -
NQS38_RS11890 (NQS38_11890) 2491673..2492401 - 729 WP_011001393.1 DsbA family protein -
NQS38_RS11895 (NQS38_11895) 2492627..2493829 - 1203 WP_064047701.1 MFS transporter -
NQS38_RS11900 (NQS38_11900) 2493826..2495163 - 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
NQS38_RS11905 (NQS38_11905) 2495167..2495421 - 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
NQS38_RS11910 (NQS38_11910) 2495525..2496364 - 840 WP_016725278.1 oxaloacetate decarboxylase -
NQS38_RS11915 (NQS38_11915) 2496682..2497320 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
NQS38_RS11920 (NQS38_11920) 2497388..2497864 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
NQS38_RS11925 (NQS38_11925) 2497884..2498435 + 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
NQS38_RS11930 (NQS38_11930) 2498432..2499358 + 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T258128 WP_069079583.1 NZ_CP104496:c2495163-2493826 [Ralstonia pseudosolanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT258128 WP_016725279.1 NZ_CP104496:c2495421-2495167 [Ralstonia pseudosolanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References