Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1053437..1055032 Replicon chromosome
Accession NZ_CP104495
Organism Ralstonia pseudosolanacearum strain Cw717

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag NQS35_RS20685 Protein ID WP_069079583.1
Coordinates 1053695..1055032 (+) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag NQS35_RS20680 Protein ID WP_016725279.1
Coordinates 1053437..1053691 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQS35_RS20655 (NQS35_20595) 1049500..1050426 - 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -
NQS35_RS20660 (NQS35_20600) 1050423..1050974 - 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
NQS35_RS20665 (NQS35_20605) 1050994..1051470 - 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
NQS35_RS20670 (NQS35_20610) 1051538..1052176 - 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
NQS35_RS20675 (NQS35_20615) 1052494..1053333 + 840 WP_016725278.1 oxaloacetate decarboxylase -
NQS35_RS20680 (NQS35_20620) 1053437..1053691 + 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
NQS35_RS20685 (NQS35_20625) 1053695..1055032 + 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
NQS35_RS20690 (NQS35_20630) 1055029..1056231 + 1203 WP_064047701.1 MFS transporter -
NQS35_RS20695 (NQS35_20635) 1056457..1057185 + 729 WP_011001393.1 DsbA family protein -
NQS35_RS20700 (NQS35_20640) 1057198..1057794 - 597 WP_016725451.1 RNA 2',3'-cyclic phosphodiesterase -
NQS35_RS20705 (NQS35_20645) 1057942..1058640 - 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
NQS35_RS20710 (NQS35_20650) 1058637..1059377 - 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T258126 WP_069079583.1 NZ_CP104495:1053695-1055032 [Ralstonia pseudosolanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT258126 WP_016725279.1 NZ_CP104495:1053437-1053691 [Ralstonia pseudosolanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References