Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4228770..4229286 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name relE Uniprot ID A0A5I8HYL8
Locus tag N4229_RS20760 Protein ID WP_050068089.1
Coordinates 4228770..4229054 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N4229_RS20765 Protein ID WP_000212724.1
Coordinates 4229044..4229286 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS20745 (4223887) 4223887..4225539 + 1653 WP_050068091.1 alpha,alpha-phosphotrehalase -
N4229_RS20750 (4225948) 4225948..4228086 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
N4229_RS20755 (4228302) 4228302..4228766 + 465 WP_050068090.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4229_RS20760 (4228770) 4228770..4229054 - 285 WP_050068089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4229_RS20765 (4229044) 4229044..4229286 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4229_RS20770 (4229364) 4229364..4231277 - 1914 WP_001212135.1 BglG family transcription antiterminator -
N4229_RS20775 (4231294) 4231294..4232034 - 741 WP_000779259.1 KDGP aldolase family protein -
N4229_RS20780 (4232031) 4232031..4233149 - 1119 WP_050068088.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N4229_RS20785 (4233133) 4233133..4234266 - 1134 WP_050068087.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10954.79 Da        Isoelectric Point: 9.8739

>T258122 WP_050068089.1 NZ_CP104491:c4229054-4228770 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSVRLNDLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258122 WP_000212724.1 NZ_CP104491:c4229286-4229044 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I8HYL8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References