Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4187546..4188096 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag N4229_RS20555 Protein ID WP_001199743.1
Coordinates 4187546..4187854 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag N4229_RS20560 Protein ID WP_000016244.1
Coordinates 4187857..4188096 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS20535 (4182588) 4182588..4182845 + 258 WP_001054380.1 YjhX family toxin -
N4229_RS20540 (4182850) 4182850..4184481 + 1632 WP_077942313.1 class I SAM-dependent methyltransferase -
N4229_RS20545 (4185040) 4185040..4185756 + 717 WP_000532939.1 YebC/PmpR family DNA-binding transcriptional regulator -
N4229_RS20550 (4186236) 4186236..4187111 - 876 WP_050068099.1 HNH endonuclease -
N4229_RS20555 (4187546) 4187546..4187854 - 309 WP_001199743.1 CcdB family protein Toxin
N4229_RS20560 (4187857) 4187857..4188096 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N4229_RS20565 (4188209) 4188209..4188457 - 249 WP_050068098.1 ribbon-helix-helix domain-containing protein -
N4229_RS20570 (4188648) 4188648..4189079 - 432 Protein_4027 helix-turn-helix domain-containing protein -
N4229_RS20580 (4189837) 4189837..4190856 + 1020 WP_050068096.1 NAD(P)-dependent alcohol dehydrogenase -
N4229_RS20585 (4190884) 4190884..4191414 - 531 WP_031605779.1 gluconokinase -
N4229_RS20590 (4191631) 4191631..4192662 + 1032 WP_050068095.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4188534..4189034 500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T258121 WP_001199743.1 NZ_CP104491:c4187854-4187546 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT258121 WP_000016244.1 NZ_CP104491:c4188096-4187857 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References