Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3548097..3548717 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4229_RS17615 Protein ID WP_001280991.1
Coordinates 3548499..3548717 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4229_RS17610 Protein ID WP_000344807.1
Coordinates 3548097..3548471 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS17600 (3543236) 3543236..3544429 + 1194 WP_050068224.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4229_RS17605 (3544452) 3544452..3547601 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N4229_RS17610 (3548097) 3548097..3548471 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4229_RS17615 (3548499) 3548499..3548717 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4229_RS17620 (3548896) 3548896..3549447 + 552 WP_001278793.1 maltose O-acetyltransferase -
N4229_RS17625 (3549565) 3549565..3550035 + 471 WP_000136183.1 YlaC family protein -
N4229_RS17630 (3550091) 3550091..3550231 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N4229_RS17635 (3550237) 3550237..3550497 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N4229_RS17640 (3550722) 3550722..3552272 + 1551 WP_050068222.1 EAL domain-containing protein -
N4229_RS17645 (3552494) 3552494..3553216 - 723 WP_050068220.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258120 WP_001280991.1 NZ_CP104491:3548499-3548717 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258120 WP_000344807.1 NZ_CP104491:3548097-3548471 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References