258114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2407262..2407784 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag N4229_RS11885 Protein ID WP_000221345.1
Coordinates 2407262..2407546 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag N4229_RS11890 Protein ID WP_000885424.1
Coordinates 2407536..2407784 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS11865 (2403337) 2403337..2404845 - 1509 WP_050067596.1 FAD-dependent oxidoreductase -
N4229_RS11870 (2404890) 2404890..2405378 + 489 WP_001293637.1 MarR family winged helix-turn-helix transcriptional regulator -
N4229_RS11875 (2405571) 2405571..2406644 + 1074 WP_050067597.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
N4229_RS11880 (2406702) 2406702..2407091 - 390 WP_001531585.1 RidA family protein -
N4229_RS11885 (2407262) 2407262..2407546 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4229_RS11890 (2407536) 2407536..2407784 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N4229_RS11895 (2408197) 2408197..2408550 - 354 WP_000418733.1 hypothetical protein -
N4229_RS11900 (2408553) 2408553..2408942 - 390 WP_001044696.1 hypothetical protein -
N4229_RS11905 (2409307) 2409307..2409423 + 117 Protein_2332 IS110 family transposase -
N4229_RS11910 (2409915) 2409915..2410247 + 333 WP_050067598.1 DUF1493 family protein -
N4229_RS11915 (2410398) 2410398..2411306 + 909 WP_077942333.1 hypothetical protein -
N4229_RS11920 (2411362) 2411362..2412075 - 714 Protein_2335 hypothetical protein -
N4229_RS11925 (2412461) 2412461..2412742 - 282 WP_024797870.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2404890..2414494 9604
- flank IS/Tn - - 2411527..2412066 539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T258114 WP_000221345.1 NZ_CP104491:c2407546-2407262 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT258114 WP_000885424.1 NZ_CP104491:c2407784-2407536 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References