Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 851170..851795 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N4229_RS04090 Protein ID WP_000911337.1
Coordinates 851397..851795 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag N4229_RS04085 Protein ID WP_000557545.1
Coordinates 851170..851397 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS04055 (846216) 846216..847314 + 1099 WP_010989230.1 peptide chain release factor 2 -
N4229_RS04060 (847324) 847324..848841 + 1518 WP_050067888.1 lysine--tRNA ligase -
N4229_RS04065 (848917) 848917..849462 - 546 WP_050067887.1 isopentenyl-diphosphate Delta-isomerase -
N4229_RS04070 (849727) 849727..850503 + 777 WP_000244321.1 amidase activator ActS -
N4229_RS04080 (850749) 850749..850961 - 213 WP_024133381.1 hypothetical protein -
N4229_RS04085 (851170) 851170..851397 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4229_RS04090 (851397) 851397..851795 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
N4229_RS04095 (852599) 852599..853135 + 537 WP_050067886.1 STM3031 family outer membrane protein -
N4229_RS04100 (853182) 853182..853814 + 633 WP_023208692.1 YfdX family protein -
N4229_RS04105 (854533) 854533..855126 + 594 WP_047606481.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 850749..860990 10241


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T258111 WP_000911337.1 NZ_CP104491:851397-851795 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT258111 WP_000557545.1 NZ_CP104491:851170-851397 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References