Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 841392..842052 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag N4229_RS04030 Protein ID WP_000244756.1
Coordinates 841639..842052 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag N4229_RS04025 Protein ID WP_000351186.1
Coordinates 841392..841658 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS04005 (837321) 837321..838754 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
N4229_RS04010 (838912) 838912..839223 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
N4229_RS04015 (839387) 839387..840046 + 660 WP_000250289.1 hemolysin III family protein -
N4229_RS04020 (840162) 840162..841142 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
N4229_RS04025 (841392) 841392..841658 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
N4229_RS04030 (841639) 841639..842052 + 414 WP_000244756.1 protein YgfX Toxin
N4229_RS04035 (842105) 842105..842626 - 522 WP_001055885.1 flavodoxin FldB -
N4229_RS04040 (842739) 842739..843635 + 897 WP_050067889.1 site-specific tyrosine recombinase XerD -
N4229_RS04045 (843659) 843659..844372 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4229_RS04050 (844378) 844378..846111 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T258110 WP_000244756.1 NZ_CP104491:841639-842052 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT258110 WP_000351186.1 NZ_CP104491:841392-841658 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References