Detailed information of TA system TA258109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 763437..765135
• Replicon: chromosome
• Accession: NZ_CP104491
• Organism: Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: N4229_RS03630
• Protein ID: WP_057935480.1
• Coordinates: 763437..764366 (-)
• Length: 310 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: N4229_RS03635
• Protein ID: WP_176202033.1
• Coordinates: 764353..765135 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4229_RS03620 (758766)	758766..762053	+	3288	WP_079953565.1	ATP-binding protein	-
N4229_RS03625 (762055)	762055..763212	+	1158	WP_057935481.1	DUF3322 domain-containing protein	-
N4229_RS03630 (763437)	763437..764366	-	930	WP_057935480.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N4229_RS03635 (764353)	764353..765135	-	783	WP_176202033.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
N4229_RS03640 (765284)	765284..766153	+	870	WP_079953566.1	hypothetical protein	-
N4229_RS03645 (766194)	766194..766988	+	795	WP_076737404.1	hypothetical protein	-
N4229_RS03650 (767331)	767331..768441	+	1111	WP_151345309.1	IS3 family transposase	-
N4229_RS03655 (768458)	768458..768637	+	180	Protein_717	zincin-like metallopeptidase domain-containing protein	-
N4229_RS03660 (768711)	768711..769202	-	492	WP_057935477.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	750856..772148	21292

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-227)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 310 a.a.
• Molecular weight: 35022.36 Da
• Isoelectric Point: 6.6425

>T258109 WP_057935480.1 NZ_CP104491:c764366-763437 [Salmonella enterica]
MDLRDSYARQVRLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKAYADRDTDLATINDALMRITESLNGR
PGITAIRQENKADEKRIIVNTADAQIKIEVSPVWRGLLLPATEMPVCEQVEMEYGFTTMNVVSQADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLTREIFDGFLCYLAGHPRPIAELLAPNWDTSRIATLYAQEFSGMTQRETSLESLLSVTTLLPQTL
KSHLTDRDRQFLLSYKQITPDWSLYRYPGIQHLPAIRWKLRNLAVLKEKNPAKYAATVNKLEGVLEQYF

Nucleotide

• Length: 930 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29289.47 Da
• Isoelectric Point: 7.8227

>AT258109 WP_176202033.1 NZ_CP104491:c765135-764353 [Salmonella enterica]
MPNYLNWLMQNTQPGQVLLQSWLTRNGIDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSAMFVTLYTSGLTVDVTPFTTTLNIGDRQLTGSVPELAAYEIA
GGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFRYLDQSDIETGTGKRQIVPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp