258106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4318974..4319755 Replicon chromosome
Accession NZ_CP104488
Organism Salmonella enterica strain SalSpp_sample_10_No.2

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag N4232_RS21350 Protein ID WP_000622305.1
Coordinates 4318974..4319465 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag N4232_RS21355 Protein ID WP_001110453.1
Coordinates 4319462..4319755 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4232_RS21325 (4314109) 4314109..4316547 - 2439 WP_001014136.1 F4 (K88) fimbrial usher FaeD -
N4232_RS21330 (4316557) 4316557..4317096 - 540 WP_000721295.1 type 1 fimbrial protein -
N4232_RS21335 (4317131) 4317131..4317415 - 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
N4232_RS21340 (4318004) 4318004..4318231 + 228 WP_001112995.1 hypothetical protein -
N4232_RS21345 (4318506) 4318506..4318739 - 234 Protein_4179 IS481 family transposase -
N4232_RS21350 (4318974) 4318974..4319465 - 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
N4232_RS21355 (4319462) 4319462..4319755 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
N4232_RS21360 (4320072) 4320072..4320294 + 223 Protein_4182 hypothetical protein -
N4232_RS21365 (4320558) 4320558..4321433 + 876 WP_000921676.1 AraC family transcriptional regulator -
N4232_RS21370 (4321430) 4321430..4321717 + 288 WP_001269916.1 transcriptional regulator RtsB -
N4232_RS21375 (4321710) 4321710..4321892 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
N4232_RS21380 (4321912) 4321912..4322011 + 100 Protein_4186 hypothetical protein -
N4232_RS21385 (4322121) 4322121..4322255 + 135 Protein_4187 hypothetical protein -
N4232_RS21390 (4322550) 4322550..4323455 - 906 WP_001268205.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4306468..4321892 15424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T258106 WP_000622305.1 NZ_CP104488:c4319465-4318974 [Salmonella enterica]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT258106 WP_001110453.1 NZ_CP104488:c4319755-4319462 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References