Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4110145..4110661 Replicon chromosome
Accession NZ_CP104488
Organism Salmonella enterica strain SalSpp_sample_10_No.2

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag N4232_RS20235 Protein ID WP_000220578.1
Coordinates 4110145..4110429 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N4232_RS20240 Protein ID WP_000212724.1
Coordinates 4110419..4110661 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4232_RS20220 (4105261) 4105261..4106913 + 1653 WP_000155039.1 alpha,alpha-phosphotrehalase -
N4232_RS20225 (4107322) 4107322..4109460 + 2139 WP_000187827.1 anaerobic ribonucleoside-triphosphate reductase -
N4232_RS20230 (4109677) 4109677..4110141 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4232_RS20235 (4110145) 4110145..4110429 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4232_RS20240 (4110419) 4110419..4110661 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4232_RS20245 (4110739) 4110739..4112652 - 1914 WP_001212145.1 BglG family transcription antiterminator -
N4232_RS20250 (4112669) 4112669..4113409 - 741 WP_000779262.1 KDGP aldolase family protein -
N4232_RS20255 (4113406) 4113406..4114524 - 1119 WP_001139165.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N4232_RS20260 (4114508) 4114508..4115641 - 1134 WP_000459952.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T258105 WP_000220578.1 NZ_CP104488:c4110429-4110145 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258105 WP_000212724.1 NZ_CP104488:c4110661-4110419 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References