258104

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4069517..4070067 Replicon chromosome
Accession NZ_CP104488
Organism Salmonella enterica strain SalSpp_sample_10_No.2

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag N4232_RS20030 Protein ID WP_001199743.1
Coordinates 4069517..4069825 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag N4232_RS20035 Protein ID WP_000016243.1
Coordinates 4069828..4070067 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4232_RS20020 (4064917) 4064917..4068432 - 3516 WP_000342548.1 AAA domain-containing protein -
N4232_RS20025 (4068794) 4068794..4069095 - 302 Protein_3920 Arm DNA-binding domain-containing protein -
N4232_RS20030 (4069517) 4069517..4069825 - 309 WP_001199743.1 CcdB family protein Toxin
N4232_RS20035 (4069828) 4069828..4070067 - 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N4232_RS20040 (4070176) 4070176..4070400 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
N4232_RS20050 (4071185) 4071185..4072204 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
N4232_RS20055 (4072232) 4072232..4072762 - 531 WP_000896756.1 gluconokinase -
N4232_RS20060 (4072979) 4072979..4074010 + 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
N4232_RS20065 (4074035) 4074035..4074799 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T258104 WP_001199743.1 NZ_CP104488:c4069825-4069517 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT258104 WP_000016243.1 NZ_CP104488:c4070067-4069828 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References