Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3393583..3394203 Replicon chromosome
Accession NZ_CP104488
Organism Salmonella enterica strain SalSpp_sample_10_No.2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4232_RS16765 Protein ID WP_001280991.1
Coordinates 3393985..3394203 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4232_RS16760 Protein ID WP_000344807.1
Coordinates 3393583..3393957 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4232_RS16750 (3388722) 3388722..3389915 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4232_RS16755 (3389938) 3389938..3393087 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N4232_RS16760 (3393583) 3393583..3393957 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4232_RS16765 (3393985) 3393985..3394203 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4232_RS16770 (3394382) 3394382..3394933 + 552 WP_001278791.1 maltose O-acetyltransferase -
N4232_RS16775 (3395051) 3395051..3395521 + 471 WP_000136183.1 YlaC family protein -
N4232_RS16780 (3395577) 3395577..3395717 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N4232_RS16785 (3395723) 3395723..3395983 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N4232_RS16790 (3396208) 3396208..3397758 + 1551 WP_000213134.1 EAL domain-containing protein -
N4232_RS16800 (3397989) 3397989..3398378 + 390 WP_000961285.1 MGMT family protein -
N4232_RS16805 (3398411) 3398411..3398980 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258103 WP_001280991.1 NZ_CP104488:3393985-3394203 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258103 WP_000344807.1 NZ_CP104488:3393583-3393957 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References