Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2388681..2389203 Replicon chromosome
Accession NZ_CP104488
Organism Salmonella enterica strain SalSpp_sample_10_No.2

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag N4232_RS11695 Protein ID WP_000221344.1
Coordinates 2388919..2389203 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag N4232_RS11690 Protein ID WP_000885424.1
Coordinates 2388681..2388929 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4232_RS11660 (2383850) 2383850..2384065 + 216 WP_001530185.1 hypothetical protein -
N4232_RS11665 (2384499) 2384499..2385422 + 924 WP_052940405.1 hypothetical protein -
N4232_RS11670 (2385837) 2385837..2386412 + 576 Protein_2287 helix-turn-helix domain-containing protein -
N4232_RS11675 (2386483) 2386483..2387433 - 951 WP_000941990.1 toll/interleukin-1 receptor domain-containing protein -
N4232_RS11680 (2387597) 2387597..2387929 - 333 WP_000253166.1 DUF1493 family protein -
N4232_RS11685 (2387923) 2387923..2388381 - 459 WP_000381836.1 hypothetical protein -
N4232_RS11690 (2388681) 2388681..2388929 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N4232_RS11695 (2388919) 2388919..2389203 + 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4232_RS11700 (2389322) 2389322..2389603 + 282 Protein_2293 RidA family protein -
N4232_RS11705 (2389655) 2389655..2390734 - 1080 WP_000954705.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
N4232_RS11710 (2390927) 2390927..2391415 - 489 WP_001293633.1 MarR family winged helix-turn-helix transcriptional regulator -
N4232_RS11715 (2391460) 2391460..2392968 + 1509 WP_000199421.1 FAD-dependent oxidoreductase -
N4232_RS11720 (2392958) 2392958..2394199 + 1242 WP_001095723.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2382938..2395825 12887
- inside Genomic island - - 2381550..2395825 14275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T258102 WP_000221344.1 NZ_CP104488:2388919-2389203 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT258102 WP_000885424.1 NZ_CP104488:2388681-2388929 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References