25809

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 756178..756866 Replicon chromosome
Accession NC_016768
Organism Mycobacterium tuberculosis KZN 4207

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag TBSG_RS03470 Protein ID WP_003403386.1
Coordinates 756178..756615 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag TBSG_RS03475 Protein ID WP_003911263.1
Coordinates 756612..756866 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBSG_RS03440 752429..753439 + 1011 WP_009938249.1 ABC transporter ATP-binding protein -
TBSG_RS03445 753827..754210 - 384 WP_003403365.1 ribonuclease VapC6 -
TBSG_RS03450 754305..754460 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
TBSG_RS03455 754536..755252 - 717 WP_009938832.1 CPBP family intramembrane metalloprotease -
TBSG_RS03460 755528..755836 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
TBSG_RS03465 755823..756068 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
TBSG_RS03470 756178..756615 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
TBSG_RS03475 756612..756866 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
TBSG_RS03480 756980..759343 + 2364 WP_003898547.1 arylsulfatase AtsD -
TBSG_RS03485 759406..759732 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TBSG_RS03490 759644..759982 + 339 WP_003403405.1 PIN domain-containing protein -
TBSG_RS03495 759979..760152 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T25809 WP_003403386.1 NC_016768:c756615-756178 [Mycobacterium tuberculosis KZN 4207]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T25809 NC_016768:c756615-756178 [Mycobacterium tuberculosis KZN 4207]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT25809 WP_003911263.1 NC_016768:c756866-756612 [Mycobacterium tuberculosis KZN 4207]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp

>AT25809 NC_016768:c756866-756612 [Mycobacterium tuberculosis KZN 4207]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References