Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4411507..4412288 Replicon chromosome
Accession NZ_CP104484
Organism Salmonella enterica strain SalSpp_sample_07_No.3

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag N4231_RS21620 Protein ID WP_000626099.1
Coordinates 4411507..4411998 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag N4231_RS21625 Protein ID WP_001110452.1
Coordinates 4411995..4412288 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4231_RS21580 (4406693) 4406693..4406935 - 243 WP_197603740.1 hypothetical protein -
N4231_RS21585 (4406932) 4406932..4407288 - 357 WP_033567083.1 hypothetical protein -
N4231_RS21590 (4407285) 4407285..4408157 - 873 WP_033567082.1 ParA family protein -
N4231_RS21595 (4408348) 4408348..4408425 - 78 Protein_4224 helix-turn-helix domain-containing protein -
N4231_RS21600 (4408516) 4408516..4408848 - 333 WP_001165471.1 MerR family transcriptional regulator -
N4231_RS21605 (4408920) 4408920..4409297 + 378 WP_000916345.1 EthD family reductase -
N4231_RS21610 (4410330) 4410330..4410404 + 75 Protein_4227 porin family protein -
N4231_RS21615 (4410507) 4410507..4411259 + 753 WP_000842434.1 non-specific acid phosphatase -
N4231_RS21620 (4411507) 4411507..4411998 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
N4231_RS21625 (4411995) 4411995..4412288 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
N4231_RS21630 (4412605) 4412605..4412826 + 222 WP_001576552.1 hypothetical protein -
N4231_RS21635 (4413091) 4413091..4413966 + 876 WP_000921674.1 AraC family transcriptional regulator -
N4231_RS21640 (4413963) 4413963..4414250 + 288 WP_001269916.1 transcriptional regulator RtsB -
N4231_RS21645 (4414273) 4414273..4414488 + 216 WP_001595136.1 hypothetical protein -
N4231_RS21650 (4414496) 4414496..4414765 + 270 WP_010989096.1 hypothetical protein -
N4231_RS21655 (4415059) 4415059..4415964 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T258089 WP_000626099.1 NZ_CP104484:c4411998-4411507 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT258089 WP_001110452.1 NZ_CP104484:c4412288-4411995 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References