Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4107168..4107744 Replicon chromosome
Accession NZ_CP104484
Organism Salmonella enterica strain SalSpp_sample_07_No.3

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag N4231_RS20120 Protein ID WP_001131963.1
Coordinates 4107457..4107744 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag N4231_RS20115 Protein ID WP_000063142.1
Coordinates 4107168..4107470 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4231_RS20100 (4103678) 4103678..4105828 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
N4231_RS20105 (4105923) 4105923..4106126 + 204 WP_000460616.1 YbdD/YjiX family protein -
N4231_RS20110 (4106137) 4106137..4107093 + 957 WP_000187839.1 GTPase -
N4231_RS20115 (4107168) 4107168..4107470 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
N4231_RS20120 (4107457) 4107457..4107744 - 288 WP_001131963.1 BrnT family toxin Toxin
N4231_RS20125 (4108013) 4108013..4108927 - 915 WP_000290512.1 restriction endonuclease -
N4231_RS20130 (4109125) 4109125..4112634 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T258087 WP_001131963.1 NZ_CP104484:c4107744-4107457 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT258087 WP_000063142.1 NZ_CP104484:c4107470-4107168 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References