258084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3489594..3490214 Replicon chromosome
Accession NZ_CP104484
Organism Salmonella enterica strain SalSpp_sample_07_No.3

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4231_RS17250 Protein ID WP_001280991.1
Coordinates 3489996..3490214 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4231_RS17245 Protein ID WP_000344807.1
Coordinates 3489594..3489968 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4231_RS17235 (3484733) 3484733..3485926 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4231_RS17240 (3485949) 3485949..3489098 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N4231_RS17245 (3489594) 3489594..3489968 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4231_RS17250 (3489996) 3489996..3490214 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4231_RS17255 (3490393) 3490393..3490944 + 552 WP_001278792.1 maltose O-acetyltransferase -
N4231_RS17260 (3491061) 3491061..3491531 + 471 WP_000136181.1 YlaC family protein -
N4231_RS17265 (3491587) 3491587..3491727 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N4231_RS17270 (3491733) 3491733..3491993 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N4231_RS17275 (3492218) 3492218..3493768 + 1551 WP_000213139.1 EAL domain-containing protein -
N4231_RS17285 (3493999) 3493999..3494388 + 390 WP_000961285.1 MGMT family protein -
N4231_RS17290 (3494421) 3494421..3494990 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258084 WP_001280991.1 NZ_CP104484:3489996-3490214 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258084 WP_000344807.1 NZ_CP104484:3489594-3489968 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References