Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4153140..4153656 Replicon chromosome
Accession NZ_CP104482
Organism Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag N4230_RS20295 Protein ID WP_000220578.1
Coordinates 4153140..4153424 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N4230_RS20300 Protein ID WP_000212724.1
Coordinates 4153414..4153656 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4230_RS20280 (4148352) 4148352..4150004 + 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -
N4230_RS20285 (4150413) 4150413..4152551 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
N4230_RS20290 (4152672) 4152672..4153136 + 465 WP_080192018.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4230_RS20295 (4153140) 4153140..4153424 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4230_RS20300 (4153414) 4153414..4153656 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4230_RS20305 (4153734) 4153734..4155647 - 1914 WP_001212135.1 BglG family transcription antiterminator -
N4230_RS20310 (4155664) 4155664..4156404 - 741 WP_000779259.1 KDGP aldolase family protein -
N4230_RS20315 (4156401) 4156401..4157519 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N4230_RS20320 (4157503) 4157503..4158636 - 1134 WP_080192019.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T258070 WP_000220578.1 NZ_CP104482:c4153424-4153140 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258070 WP_000212724.1 NZ_CP104482:c4153656-4153414 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References