Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3454996..3455616 Replicon chromosome
Accession NZ_CP104482
Organism Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4230_RS17080 Protein ID WP_001280991.1
Coordinates 3455398..3455616 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4230_RS17075 Protein ID WP_000344807.1
Coordinates 3454996..3455370 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4230_RS17065 (3450135) 3450135..3451328 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4230_RS17070 (3451351) 3451351..3454500 + 3150 WP_260973691.1 efflux RND transporter permease AcrB -
N4230_RS17075 (3454996) 3454996..3455370 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4230_RS17080 (3455398) 3455398..3455616 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4230_RS17085 (3455795) 3455795..3456346 + 552 WP_001278793.1 maltose O-acetyltransferase -
N4230_RS17090 (3456463) 3456463..3456933 + 471 WP_000136181.1 YlaC family protein -
N4230_RS17095 (3456989) 3456989..3457129 - 141 WP_020839525.1 type B 50S ribosomal protein L36 -
N4230_RS17100 (3457135) 3457135..3457395 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
N4230_RS17105 (3457620) 3457620..3459170 + 1551 WP_080192107.1 EAL domain-containing protein -
N4230_RS17115 (3459401) 3459401..3459790 + 390 WP_000961285.1 MGMT family protein -
N4230_RS17120 (3459823) 3459823..3460392 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258067 WP_001280991.1 NZ_CP104482:3455398-3455616 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258067 WP_000344807.1 NZ_CP104482:3454996-3455370 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References