Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2401920..2402442 Replicon chromosome
Accession NZ_CP104482
Organism Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag N4230_RS11800 Protein ID WP_000221343.1
Coordinates 2402158..2402442 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID -
Locus tag N4230_RS11795 Protein ID WP_080192115.1
Coordinates 2401920..2402168 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4230_RS11765 (2397305) 2397305..2398771 + 1467 WP_079960978.1 hypothetical protein -
N4230_RS11770 (2399073) 2399073..2399363 + 291 WP_000742001.1 hypothetical protein -
N4230_RS11775 (2399729) 2399729..2400464 + 736 Protein_2300 helix-turn-helix domain-containing protein -
N4230_RS11780 (2400520) 2400520..2400951 - 432 WP_080192144.1 hypothetical protein -
N4230_RS11785 (2401231) 2401231..2401563 - 333 WP_080192116.1 DUF1493 family protein -
N4230_RS11790 (2401553) 2401553..2401768 - 216 WP_000206207.1 hypothetical protein -
N4230_RS11795 (2401920) 2401920..2402168 + 249 WP_080192115.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N4230_RS11800 (2402158) 2402158..2402442 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4230_RS11805 (2402613) 2402613..2403002 + 390 WP_000194089.1 RidA family protein -
N4230_RS11810 (2403054) 2403054..2404133 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
N4230_RS11815 (2404326) 2404326..2404814 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
N4230_RS11820 (2404859) 2404859..2406367 + 1509 WP_058214747.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2397308..2409224 11916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T258066 WP_000221343.1 NZ_CP104482:2402158-2402442 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9820

>AT258066 WP_080192115.1 NZ_CP104482:2401920-2402168 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERIIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure

References