Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1012261..1013075 Replicon chromosome
Accession NZ_CP104482
Organism Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A7U1KVS1
Locus tag N4230_RS04820 Protein ID WP_058653211.1
Coordinates 1012261..1012788 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag N4230_RS04825 Protein ID WP_000855694.1
Coordinates 1012785..1013075 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4230_RS04790 (1007538) 1007538..1008020 + 483 Protein_939 hypothetical protein -
N4230_RS04800 (1009618) 1009618..1010286 + 669 WP_000445914.1 hypothetical protein -
N4230_RS04805 (1010313) 1010313..1010807 + 495 WP_020899151.1 hypothetical protein -
N4230_RS04810 (1010979) 1010979..1011635 - 657 WP_093984237.1 protein-serine/threonine phosphatase -
N4230_RS04815 (1011973) 1011973..1012188 + 216 Protein_944 IS5/IS1182 family transposase -
N4230_RS04820 (1012261) 1012261..1012788 - 528 WP_058653211.1 GNAT family N-acetyltransferase Toxin
N4230_RS04825 (1012785) 1012785..1013075 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
N4230_RS04830 (1013345) 1013345..1013523 - 179 Protein_947 IS3 family transposase -
N4230_RS04835 (1013764) 1013764..1014090 + 327 WP_000393302.1 hypothetical protein -
N4230_RS04840 (1014363) 1014363..1014710 - 348 WP_001669174.1 DUF1493 family protein -
N4230_RS04845 (1014695) 1014695..1015144 - 450 WP_000381617.1 hypothetical protein -
N4230_RS04850 (1015576) 1015576..1016019 - 444 WP_080110658.1 SPI-1 type III secretion system invasion lipoprotein InvH -
N4230_RS04855 (1016476) 1016476..1017126 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - invH 1000177..1016019 15842


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19051.87 Da        Isoelectric Point: 9.6420

>T258061 WP_058653211.1 NZ_CP104482:c1012788-1012261 [Salmonella enterica]
MMFTDWHEAAIGKTHNRINFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT258061 WP_000855694.1 NZ_CP104482:c1013075-1012785 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1KVS1

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References