Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 851930..852555 Replicon chromosome
Accession NZ_CP104482
Organism Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)


Gene name vapC Uniprot ID A0A5I5T1K0
Locus tag N4230_RS04105 Protein ID WP_001748684.1
Coordinates 852157..852555 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag N4230_RS04100 Protein ID WP_000557545.1
Coordinates 851930..852157 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4230_RS04070 (846943) 846943..848460 + 1518 WP_000003339.1 lysine--tRNA ligase -
N4230_RS04075 (848536) 848536..849081 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
N4230_RS04080 (849346) 849346..850104 + 759 WP_000244325.1 amidase activator ActS -
N4230_RS04090 (850389) 850389..851195 - 807 WP_077907190.1 DUF1460 domain-containing protein -
N4230_RS04095 (851470) 851470..851721 - 252 WP_001748683.1 hypothetical protein -
N4230_RS04100 (851930) 851930..852157 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4230_RS04105 (852157) 852157..852555 + 399 WP_001748684.1 tRNA(fMet)-specific endonuclease VapC Toxin
N4230_RS04110 (853361) 853361..853897 + 537 WP_001038506.1 STM3031 family outer membrane protein -
N4230_RS04115 (853944) 853944..854576 + 633 WP_000835265.1 YfdX family protein -
N4230_RS04120 (855295) 855295..855882 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 850389..861713 11324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14995.39 Da        Isoelectric Point: 7.7780

>T258060 WP_001748684.1 NZ_CP104482:852157-852555 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHVKERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT258060 WP_000557545.1 NZ_CP104482:851930-852157 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5T1K0

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References