Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4409486..4410267 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag N4G50_RS21695 Protein ID WP_000625911.1
Coordinates 4409486..4409977 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag N4G50_RS21700 Protein ID WP_001110450.1
Coordinates 4409974..4410267 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS21670 (4406366) 4406366..4407196 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
N4G50_RS21675 (4407398) 4407398..4407610 - 213 WP_001293880.1 PapB/FocB family fimbrial expression transcriptional regulator -
N4G50_RS21680 (4408236) 4408236..4408379 + 144 Protein_4242 transposase -
N4G50_RS21685 (4408396) 4408396..4408742 + 347 Protein_4243 Rpn family recombination-promoting nuclease/putative transposase -
N4G50_RS21690 (4409023) 4409023..4409271 - 249 Protein_4244 IS481 family transposase -
N4G50_RS21695 (4409486) 4409486..4409977 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
N4G50_RS21700 (4409974) 4409974..4410267 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
N4G50_RS21705 (4410584) 4410584..4410805 + 222 WP_001595143.1 hypothetical protein -
N4G50_RS21710 (4411071) 4411071..4411946 + 876 WP_017441228.1 AraC family transcriptional regulator -
N4G50_RS21715 (4411943) 4411943..4412230 + 288 WP_001269916.1 transcriptional regulator RtsB -
N4G50_RS21720 (4412223) 4412223..4412405 - 183 WP_023252989.1 ATP-binding cassette domain-containing protein -
N4G50_RS21725 (4412425) 4412425..4412524 + 100 Protein_4251 hypothetical protein -
N4G50_RS21730 (4412635) 4412635..4412766 + 132 Protein_4252 hypothetical protein -
N4G50_RS21735 (4413061) 4413061..4413966 - 906 WP_038806641.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4398895..4412405 13510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T258055 WP_000625911.1 NZ_CP104479:c4409977-4409486 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT258055 WP_001110450.1 NZ_CP104479:c4410267-4409974 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References