258054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4272149..4272665 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag N4G50_RS20975 Protein ID WP_000220578.1
Coordinates 4272149..4272433 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag N4G50_RS20980 Protein ID WP_000212724.1
Coordinates 4272423..4272665 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS20960 (4267265) 4267265..4268917 + 1653 WP_024156574.1 alpha,alpha-phosphotrehalase -
N4G50_RS20965 (4269326) 4269326..4271464 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
N4G50_RS20970 (4271681) 4271681..4272145 + 465 WP_024156575.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N4G50_RS20975 (4272149) 4272149..4272433 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4G50_RS20980 (4272423) 4272423..4272665 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4G50_RS20985 (4272743) 4272743..4274656 - 1914 WP_024156576.1 BglG family transcription antiterminator -
N4G50_RS20990 (4274673) 4274673..4275413 - 741 WP_000779252.1 KDGP aldolase family protein -
N4G50_RS20995 (4275410) 4275410..4276528 - 1119 WP_024156577.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
N4G50_RS21000 (4276512) 4276512..4277645 - 1134 WP_024156578.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T258054 WP_000220578.1 NZ_CP104479:c4272433-4272149 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT258054 WP_000212724.1 NZ_CP104479:c4272665-4272423 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References