Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4231560..4232110 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag N4G50_RS20770 Protein ID WP_001199743.1
Coordinates 4231560..4231868 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag N4G50_RS20775 Protein ID WP_000016244.1
Coordinates 4231871..4232110 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS20760 (4229523) 4229523..4229810 - 288 WP_024156563.1 Arm DNA-binding domain-containing protein -
N4G50_RS20770 (4231560) 4231560..4231868 - 309 WP_001199743.1 CcdB family protein Toxin
N4G50_RS20775 (4231871) 4231871..4232110 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N4G50_RS20780 (4232219) 4232219..4232443 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
N4G50_RS20790 (4233227) 4233227..4234246 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
N4G50_RS20795 (4234274) 4234274..4234804 - 531 WP_000896758.1 gluconokinase -
N4G50_RS20800 (4235021) 4235021..4236052 + 1032 WP_023181345.1 L-idonate 5-dehydrogenase -
N4G50_RS20805 (4236077) 4236077..4236841 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4217713..4232110 14397


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T258053 WP_001199743.1 NZ_CP104479:c4231868-4231560 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT258053 WP_000016244.1 NZ_CP104479:c4232110-4231871 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References