258050

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3573751..3574371 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag N4G50_RS17745 Protein ID WP_001280991.1
Coordinates 3574153..3574371 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag N4G50_RS17740 Protein ID WP_000344807.1
Coordinates 3573751..3574125 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS17730 (3568890) 3568890..3570083 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N4G50_RS17735 (3570106) 3570106..3573255 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
N4G50_RS17740 (3573751) 3573751..3574125 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
N4G50_RS17745 (3574153) 3574153..3574371 + 219 WP_001280991.1 HHA domain-containing protein Toxin
N4G50_RS17750 (3574550) 3574550..3575101 + 552 WP_001278793.1 maltose O-acetyltransferase -
N4G50_RS17755 (3575218) 3575218..3575688 + 471 WP_024156787.1 YlaC family protein -
N4G50_RS17760 (3575743) 3575743..3575883 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
N4G50_RS17765 (3575889) 3575889..3576149 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
N4G50_RS17770 (3576374) 3576374..3577924 + 1551 WP_260944304.1 EAL domain-containing protein -
N4G50_RS17780 (3578155) 3578155..3578544 + 390 WP_000961285.1 MGMT family protein -
N4G50_RS17785 (3578577) 3578577..3579146 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T258050 WP_001280991.1 NZ_CP104479:3574153-3574371 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT258050 WP_000344807.1 NZ_CP104479:3573751-3574125 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References