258049

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2462268..2462790 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag N4G50_RS12115 Protein ID WP_000221343.1
Coordinates 2462506..2462790 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag N4G50_RS12110 Protein ID WP_000885424.1
Coordinates 2462268..2462516 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS12090 (2458678) 2458678..2459658 - 981 WP_024156973.1 nitronate monooxygenase -
N4G50_RS12095 (2459832) 2459832..2460740 - 909 WP_001176641.1 LysR family transcriptional regulator -
N4G50_RS12100 (2461153) 2461153..2461341 + 189 WP_001276021.1 DUF29 family protein -
N4G50_RS12105 (2461616) 2461616..2461783 - 168 Protein_2366 DUF1493 family protein -
N4G50_RS12110 (2462268) 2462268..2462516 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N4G50_RS12115 (2462506) 2462506..2462790 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4G50_RS12120 (2462961) 2462961..2463350 + 390 WP_023206403.1 RidA family protein -
N4G50_RS12125 (2463402) 2463402..2464481 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
N4G50_RS12130 (2464674) 2464674..2465162 - 489 WP_024156974.1 MarR family winged helix-turn-helix transcriptional regulator -
N4G50_RS12135 (2465207) 2465207..2466715 + 1509 WP_024156975.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2456960..2469572 12612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T258049 WP_000221343.1 NZ_CP104479:2462506-2462790 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT258049 WP_000885424.1 NZ_CP104479:2462268-2462516 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References