Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870876..871536 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag N4G50_RS04215 Protein ID WP_000244756.1
Coordinates 871123..871536 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag N4G50_RS04210 Protein ID WP_000351186.1
Coordinates 870876..871142 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS04190 (866804) 866804..868237 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
N4G50_RS04195 (868396) 868396..868707 + 312 WP_024156669.1 N(4)-acetylcytidine aminohydrolase -
N4G50_RS04200 (868871) 868871..869530 + 660 WP_000250289.1 hemolysin III family protein -
N4G50_RS04205 (869646) 869646..870626 - 981 WP_000874169.1 tRNA-modifying protein YgfZ -
N4G50_RS04210 (870876) 870876..871142 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
N4G50_RS04215 (871123) 871123..871536 + 414 WP_000244756.1 protein YgfX Toxin
N4G50_RS04220 (871589) 871589..872110 - 522 WP_001055885.1 flavodoxin FldB -
N4G50_RS04225 (872223) 872223..873119 + 897 WP_000434303.1 site-specific tyrosine recombinase XerD -
N4G50_RS04230 (873143) 873143..873856 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N4G50_RS04235 (873862) 873862..875595 + 1734 WP_024156668.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T258042 WP_000244756.1 NZ_CP104479:871123-871536 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT258042 WP_000351186.1 NZ_CP104479:870876-871142 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References