Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 209720..210480 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag N4G50_RS01010 Protein ID WP_000533909.1
Coordinates 209995..210480 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag N4G50_RS01005 Protein ID WP_000965889.1
Coordinates 209720..210007 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS00985 (205050) 205050..205961 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
N4G50_RS00990 (205971) 205971..208040 + 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
N4G50_RS00995 (208502) 208502..208933 + 432 Protein_197 IS3 family transposase -
N4G50_RS01000 (209075) 209075..209542 + 468 WP_024156875.1 GNAT family N-acetyltransferase -
N4G50_RS01005 (209720) 209720..210007 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
N4G50_RS01010 (209995) 209995..210480 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
N4G50_RS01015 (210851) 210851..211390 - 540 WP_000047139.1 copper-binding periplasmic metallochaperone CueP -
N4G50_RS01020 (211563) 211563..211775 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
N4G50_RS01025 (212063) 212063..212353 - 291 WP_000455790.1 HTH-type transcriptional regulator -
N4G50_RS01030 (212792) 212792..213502 + 711 WP_000190524.1 DUF3053 domain-containing protein -
N4G50_RS01035 (213552) 213552..214526 - 975 WP_024156876.1 glyoxylate/hydroxypyruvate reductase GhrB -
N4G50_RS01040 (214756) 214756..215418 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T258039 WP_000533909.1 NZ_CP104479:209995-210480 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT258039 WP_000965889.1 NZ_CP104479:209720-210007 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References