Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2087217..2087731 Replicon chromosome
Accession NZ_CP104478
Organism Staphylococcus aureus strain DSM 20231

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag N1060_RS10305 Protein ID WP_000581792.1
Coordinates 2087217..2087426 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag N1060_RS10310 Protein ID WP_000138932.1
Coordinates 2087438..2087731 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1060_RS10285 (N1060_10285) 2082725..2084083 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
N1060_RS10290 (N1060_10290) 2084098..2085168 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
N1060_RS10295 (N1060_10295) 2085486..2086688 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
N1060_RS10300 (N1060_10300) 2086952..2087089 - 138 WP_000828354.1 Lmo0850 family protein -
N1060_RS10305 (N1060_10305) 2087217..2087426 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
N1060_RS10310 (N1060_10310) 2087438..2087731 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
N1060_RS10315 (N1060_10315) 2087897..2089381 + 1485 WP_000571549.1 cardiolipin synthase -
N1060_RS10320 (N1060_10320) 2089409..2090056 + 648 WP_001187629.1 HD domain-containing protein -
N1060_RS10325 (N1060_10325) 2090869..2091741 - 873 WP_000725802.1 membrane protein insertase YidC -
N1060_RS10330 (N1060_10330) 2091827..2092468 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T258034 WP_000581792.1 NZ_CP104478:c2087426-2087217 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT258034 WP_000138932.1 NZ_CP104478:c2087731-2087438 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References