258033

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2067460..2067989 Replicon chromosome
Accession NZ_CP104478
Organism Staphylococcus aureus strain DSM 20231

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N1060_RS10215 Protein ID WP_000621175.1
Coordinates 2067460..2067822 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag N1060_RS10220 Protein ID WP_000948331.1
Coordinates 2067819..2067989 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1060_RS10195 (N1060_10195) 2064440..2065210 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
N1060_RS10200 (N1060_10200) 2065185..2065664 - 480 WP_001190829.1 anti-sigma B factor RsbW -
N1060_RS10205 (N1060_10205) 2065666..2065992 - 327 WP_001052491.1 anti-sigma factor antagonist -
N1060_RS10210 (N1060_10210) 2066111..2067112 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
N1060_RS10215 (N1060_10215) 2067460..2067822 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N1060_RS10220 (N1060_10220) 2067819..2067989 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
N1060_RS10225 (N1060_10225) 2068074..2069222 - 1149 WP_001281145.1 alanine racemase -
N1060_RS10230 (N1060_10230) 2069288..2069647 - 360 WP_000581200.1 holo-ACP synthase -
N1060_RS10235 (N1060_10235) 2069651..2070142 - 492 WP_001205910.1 PH domain-containing protein -
N1060_RS10240 (N1060_10240) 2070129..2071712 - 1584 WP_001294626.1 PH domain-containing protein -
N1060_RS10245 (N1060_10245) 2071705..2072184 - 480 WP_001287088.1 hypothetical protein -
N1060_RS10250 (N1060_10250) 2072393..2072953 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T258033 WP_000621175.1 NZ_CP104478:c2067822-2067460 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT258033 WP_000948331.1 NZ_CP104478:c2067989-2067819 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References