258032

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1909446..1910222 Replicon chromosome
Accession NZ_CP104478
Organism Staphylococcus aureus strain DSM 20231

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag N1060_RS09300 Protein ID WP_000031108.1
Coordinates 1909446..1909598 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag N1060_RS09305 Protein ID WP_001251224.1
Coordinates 1909623..1910222 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1060_RS09285 (N1060_09285) 1905409..1906230 + 822 WP_000669376.1 RluA family pseudouridine synthase -
N1060_RS09290 (N1060_09290) 1906693..1908078 - 1386 WP_000116224.1 class II fumarate hydratase -
N1060_RS09295 (N1060_09295) 1908274..1908669 - 396 WP_000901021.1 hypothetical protein -
N1060_RS09300 (N1060_09300) 1909446..1909598 - 153 WP_000031108.1 SAS053 family protein Toxin
N1060_RS09305 (N1060_09305) 1909623..1910222 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
N1060_RS09310 (N1060_09310) 1910381..1910851 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
N1060_RS09315 (N1060_09315) 1910856..1911983 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
N1060_RS09320 (N1060_09320) 1912134..1912856 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
N1060_RS09325 (N1060_09325) 1912849..1914306 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T258032 WP_000031108.1 NZ_CP104478:c1909598-1909446 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT258032 WP_001251224.1 NZ_CP104478:c1910222-1909623 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References