Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2087219..2087733 Replicon chromosome
Accession NZ_CP104476
Organism Staphylococcus aureus strain DSM 20231-Res2

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag N2W57_RS10305 Protein ID WP_000581792.1
Coordinates 2087219..2087428 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag N2W57_RS10310 Protein ID WP_000138932.1
Coordinates 2087440..2087733 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2W57_RS10285 (N2W57_10285) 2082727..2084085 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
N2W57_RS10290 (N2W57_10290) 2084100..2085170 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
N2W57_RS10295 (N2W57_10295) 2085488..2086690 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
N2W57_RS10300 (N2W57_10300) 2086954..2087091 - 138 WP_000828354.1 Lmo0850 family protein -
N2W57_RS10305 (N2W57_10305) 2087219..2087428 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
N2W57_RS10310 (N2W57_10310) 2087440..2087733 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
N2W57_RS10315 (N2W57_10315) 2087899..2089383 + 1485 WP_000571549.1 cardiolipin synthase -
N2W57_RS10320 (N2W57_10320) 2089411..2090058 + 648 WP_001187629.1 HD domain-containing protein -
N2W57_RS10325 (N2W57_10325) 2090871..2091743 - 873 WP_000725802.1 membrane protein insertase YidC -
N2W57_RS10330 (N2W57_10330) 2091829..2092470 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T258025 WP_000581792.1 NZ_CP104476:c2087428-2087219 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT258025 WP_000138932.1 NZ_CP104476:c2087733-2087440 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References