258024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2067462..2067991 Replicon chromosome
Accession NZ_CP104476
Organism Staphylococcus aureus strain DSM 20231-Res2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N2W57_RS10215 Protein ID WP_000621175.1
Coordinates 2067462..2067824 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag N2W57_RS10220 Protein ID WP_000948331.1
Coordinates 2067821..2067991 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2W57_RS10195 (N2W57_10195) 2064442..2065212 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
N2W57_RS10200 (N2W57_10200) 2065187..2065666 - 480 WP_001190829.1 anti-sigma B factor RsbW -
N2W57_RS10205 (N2W57_10205) 2065668..2065994 - 327 WP_001052491.1 anti-sigma factor antagonist -
N2W57_RS10210 (N2W57_10210) 2066113..2067114 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
N2W57_RS10215 (N2W57_10215) 2067462..2067824 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N2W57_RS10220 (N2W57_10220) 2067821..2067991 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
N2W57_RS10225 (N2W57_10225) 2068076..2069224 - 1149 WP_001281145.1 alanine racemase -
N2W57_RS10230 (N2W57_10230) 2069290..2069649 - 360 WP_000581200.1 holo-ACP synthase -
N2W57_RS10235 (N2W57_10235) 2069653..2070144 - 492 WP_001205910.1 PH domain-containing protein -
N2W57_RS10240 (N2W57_10240) 2070131..2071714 - 1584 WP_001294626.1 PH domain-containing protein -
N2W57_RS10245 (N2W57_10245) 2071707..2072186 - 480 WP_001287088.1 hypothetical protein -
N2W57_RS10250 (N2W57_10250) 2072395..2072955 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T258024 WP_000621175.1 NZ_CP104476:c2067824-2067462 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT258024 WP_000948331.1 NZ_CP104476:c2067991-2067821 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References