Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1909448..1910224 Replicon chromosome
Accession NZ_CP104476
Organism Staphylococcus aureus strain DSM 20231-Res2

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag N2W57_RS09300 Protein ID WP_000031108.1
Coordinates 1909448..1909600 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag N2W57_RS09305 Protein ID WP_001251224.1
Coordinates 1909625..1910224 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2W57_RS09285 (N2W57_09285) 1905411..1906232 + 822 WP_000669376.1 RluA family pseudouridine synthase -
N2W57_RS09290 (N2W57_09290) 1906695..1908080 - 1386 WP_000116224.1 class II fumarate hydratase -
N2W57_RS09295 (N2W57_09295) 1908276..1908671 - 396 WP_000901021.1 hypothetical protein -
N2W57_RS09300 (N2W57_09300) 1909448..1909600 - 153 WP_000031108.1 SAS053 family protein Toxin
N2W57_RS09305 (N2W57_09305) 1909625..1910224 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
N2W57_RS09310 (N2W57_09310) 1910383..1910853 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
N2W57_RS09315 (N2W57_09315) 1910858..1911985 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
N2W57_RS09320 (N2W57_09320) 1912136..1912858 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
N2W57_RS09325 (N2W57_09325) 1912851..1914308 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T258023 WP_000031108.1 NZ_CP104476:c1909600-1909448 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT258023 WP_001251224.1 NZ_CP104476:c1910224-1909625 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References