Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4067077..4067695 Replicon chromosome
Accession NZ_CP104472
Organism Escherichia coli strain UC4224

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N4S17_RS19555 Protein ID WP_001291435.1
Coordinates 4067077..4067295 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N4S17_RS19560 Protein ID WP_000344800.1
Coordinates 4067321..4067695 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4S17_RS19520 (4062367) 4062367..4062939 + 573 WP_000779826.1 YbaY family lipoprotein -
N4S17_RS19525 (4062970) 4062970..4063281 - 312 WP_000409911.1 MGMT family protein -
N4S17_RS19535 (4063660) 4063660..4064013 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N4S17_RS19540 (4064055) 4064055..4065605 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N4S17_RS19545 (4065769) 4065769..4066239 - 471 WP_000136192.1 YlaC family protein -
N4S17_RS19550 (4066355) 4066355..4066906 - 552 WP_000102564.1 maltose O-acetyltransferase -
N4S17_RS19555 (4067077) 4067077..4067295 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N4S17_RS19560 (4067321) 4067321..4067695 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N4S17_RS19565 (4068241) 4068241..4071390 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N4S17_RS19570 (4071413) 4071413..4072606 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T258009 WP_001291435.1 NZ_CP104472:c4067295-4067077 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT258009 WP_000344800.1 NZ_CP104472:c4067695-4067321 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References