Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3347768..3348363 Replicon chromosome
Accession NZ_CP104472
Organism Escherichia coli strain UC4224

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N4S17_RS16165 Protein ID WP_000239579.1
Coordinates 3348013..3348363 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag N4S17_RS16160 Protein ID WP_001223208.1
Coordinates 3347768..3348019 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4S17_RS16150 (3343433) 3343433..3347212 + 3780 WP_028985281.1 autotransporter assembly complex protein TamB -
N4S17_RS16155 (3347215) 3347215..3347556 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N4S17_RS16160 (3347768) 3347768..3348019 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N4S17_RS16165 (3348013) 3348013..3348363 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N4S17_RS16170 (3348443) 3348443..3348973 - 531 WP_000055072.1 inorganic diphosphatase -
N4S17_RS16175 (3349283) 3349283..3350239 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N4S17_RS16180 (3350549) 3350549..3352051 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
N4S17_RS16185 (3352065) 3352065..3353087 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T258004 WP_000239579.1 NZ_CP104472:3348013-3348363 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT258004 WP_001223208.1 NZ_CP104472:3347768-3348019 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References