Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1322781..1323406 Replicon chromosome
Accession NZ_CP104472
Organism Escherichia coli strain UC4224

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag N4S17_RS06445 Protein ID WP_000911329.1
Coordinates 1322781..1323179 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N4S17_RS06450 Protein ID WP_000450524.1
Coordinates 1323179..1323406 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4S17_RS06425 (1318659) 1318659..1318859 + 201 WP_000383836.1 YpfN family protein -
N4S17_RS06430 (1318969) 1318969..1319667 - 699 WP_000679812.1 esterase -
N4S17_RS06435 (1319741) 1319741..1321756 - 2016 WP_028985187.1 tRNA cytosine(34) acetyltransferase TmcA -
N4S17_RS06440 (1321771) 1321771..1322634 - 864 WP_001267498.1 neutral zinc metallopeptidase -
N4S17_RS06445 (1322781) 1322781..1323179 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
N4S17_RS06450 (1323179) 1323179..1323406 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N4S17_RS06455 (1323561) 1323561..1324274 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N4S17_RS06460 (1324487) 1324487..1325521 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N4S17_RS06465 (1325538) 1325538..1326416 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N4S17_RS06470 (1326562) 1326562..1327134 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N4S17_RS06475 (1327134) 1327134..1327604 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T257995 WP_000911329.1 NZ_CP104472:c1323179-1322781 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT257995 WP_000450524.1 NZ_CP104472:c1323406-1323179 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References