Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 186880..187518 Replicon chromosome
Accession NZ_CP104472
Organism Escherichia coli strain UC4224

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N4S17_RS00900 Protein ID WP_000813794.1
Coordinates 186880..187056 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N4S17_RS00905 Protein ID WP_001270286.1
Coordinates 187102..187518 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4S17_RS00880 (182499) 182499..183674 - 1176 WP_001236296.1 BenE family transporter YdcO -
N4S17_RS00885 (183766) 183766..184302 + 537 WP_000429152.1 DNA-binding transcriptional regulator SutR -
N4S17_RS00890 (184375) 184375..186336 + 1962 WP_001442195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N4S17_RS00895 (186428) 186428..186658 - 231 WP_000494244.1 YncJ family protein -
N4S17_RS00900 (186880) 186880..187056 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N4S17_RS00905 (187102) 187102..187518 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N4S17_RS00910 (187597) 187597..189003 + 1407 WP_000760615.1 PLP-dependent aminotransferase family protein -
N4S17_RS00915 (189248) 189248..190393 + 1146 WP_000047456.1 ABC transporter substrate-binding protein -
N4S17_RS00920 (190411) 190411..191424 + 1014 WP_001583503.1 ABC transporter ATP-binding protein -
N4S17_RS00925 (191425) 191425..192366 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257987 WP_000813794.1 NZ_CP104472:186880-187056 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257987 WP_001270286.1 NZ_CP104472:187102-187518 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References